PharmaCircle NewsLetter for Week of 9/17/2007

Newly Added/Updated Companies:  AcelRx (buccal/sublingual), InnFocus LLC (ocular implants)

Technology Deals

• Adams Respiratory Therapeutics and Lipocine Enter into License and Collaboration Agreement 9/19 - Press Release
• Carrington Subsidiary DelSite Biotechnologies Enters into Technology Evaluation Rights License Agreement for Transdermal Delivery of Vaccines 9/19 - PR Newswire

Acquisitions

• Bausch & Lomb Shareholders Approve Merger with Affiliates of Warburg Pincus 9/21 - Press Release

• Allergan, Inc. Announces Agreement to Acquire Esprit Pharma, Inc. 9/19 - Press Release

• Sontra Medical and Echo Therapeutics Announce Merger 9/17 - PR Newswire

Product Filings

• FDA Accepts Sucampo's sNDA for Lubiprostone (8 mcg) for the Treatment of Irritable Bowel Syndrome with Constipation (IBS-C) 9/17 - Press Release

Product Approvals

• Norditropin(R) Approved for Treatment of Children with Short Stature Associated with Turner Syndrome 9/21 - PR Newswire
• Taro Receives FDA Approvals for Ciclopirox Topical Solution, 8% (Nail Lacquer) and Grape Flavor Formulation of Loratadine Syrup, 5mg 9/20 - Press Release
• Novo Nordisk Receives Approval in the EU for use of NovoRapid® in Elderly People 9/20 - Press Release
• Perrigo Company Announces FDA Approval for Ciclopirox Topical Solution 9/19 - PR Newswire
• Hi-Tech Pharmacal Receives Approval for Ciclopirox Topical Solution 9/19 - Press Release

Product Deals

• EUSA Pharma Signs Exclusive Distribution Agreement With Samaritan for Anesthetic Pain Patch to Launch and Sell in Greece and Cyprus 9/20 - Press Release

• Alnylam Announces the Termination of its Collaboration with Merck & Co., Inc. 9/19 - Press Release

• Futura and SSL Sign Global Development and Licensing Agreement for MED2002 9/17 - Press Release

Product News

• The CYPHER(R) Sirolimus-Eluting Coronary Stent Outperforms the Taxus Stent in Small Coronary Vessels According to New Clinical Data Analysis Published in the Journal of the American College of Cardiology 9/21 - Business wire
• Vaccination and Enrollment Are Discontinued in Phase II Trials of Merck's Investigational HIV Vaccine Candidate 9/21 - Business wire
• NeurogesX Completes Enrollment in Confirmatory Phase 3 Clinical Trial for Painful HIV Distal Sensory Polyneuropathy 9/21 - Press Release
• Maxygen Announces Hold on MAXY-alpha Development Program 9/21 - Press Release
• ThromboGenics Completes Enrolment of Patients for the Vitreomacular Traction Trial 9/21 - Press Release
• One Year Study of Exenatide Treatment Showed Improved Beta-Cell Function 9/21 - PR Newswire
• CELSION Provides Update on Status of Special Protocol Assessment (SPA) Submission  9/21 - Press Release
• Arpida Presents Preclinical Data on AR-2474 at ICAAC 9/20 - Press Release
• Angiotech Announces Further European Expansion of the Quill™ SRS PDO Product Line 9/20 - Press Release
• JDRF Partners with CoMentis for Diabetic Macular Edema Clinical Trial  9/20 - Press Release
• New Data Confirms NovoMix® 30 is Associated With Significantly Fewer Night-time and Major Hypoglycaemic Events than Biphasic Human Insulin (BHI) 9/20 - Press Release
• Vical Licensee Sanofi-aventis Initiates Phase 3 Trial to Reduce Amputations 9/20 - Press Release
• Zelos Therapeutics Presents Positive Data at ASBMR on Subcutaneous and Inhaled Delivery of Cyclic PTH (1-31) (Ostabolin-C™) 9/19 - Press Release
• Metabasis Therapeutics Announces the First Publication on MB07811, Its Novel Product Candidate for the Treatment of Hyperlipidemia, in the Proceedings of the National Academy of Sciences 9/19 - Press Release
• Alexza to Initiate the First Phase 3 Trial for AZ-004 (Staccato(R) Loxapine) in Late Q1 2008 9/19 - Pres Release
• Depomed Completes Patient Enrollment in Phase 2 Trial for Gabapentin GR for the Treatment of Menopausal Hot Flashes 9/19 - Press Release
• FDA Approves Expanded Label for FluMist(R) to Include Children Two to Five Years of Age 9/19 - Press Release
• Iomai Patch-Based Vaccine Cut Rate of Travelers' Diarrhea by 75 Percent in Phase 2 Field Study 9/18 - Press Release
• Aclidinium Bromide Demonstrates Rapid and Long-Acting Bronchodilatory Effect in COPD 9/18 - Press Release
• Aphios Awarded STTR Grant from NCI for Nanosomal Formulation of Novel, Nontoxic Vitamin D Analog for Hormone Refractory Prostate Cancer 9/18 - Business wire
• Study Demonstrates Aerosolized Prolastin® Using Unique Nebulizer Results in High Levels of Drug Deposited in Peripheral Regions of Lungs 9/18 - Press Release
• New Data Support Long-Term Efficacy and Safety in Patients Who Took Exubera for Eight Years 9/18 - Press Release
• Genta Initiates First Clinical Trial with New Oral Drug (G4544) to Treat Bone Disease 9/17 - Press Release
• Targeted Genetics Reports on Recombinant DNA Advisory Committee (RAC) Review of its Phase 1/2 Trial of tgAAC94 for Rheumatoid Arthritis 9/17 - Press Release
• AlphaRx To Present at 47th Annual ICAAC  9/17 - Press Release
• Phosphagenics to Conduct a Phase 1 Transdermal Oxycodone Clinical Trial 9/17 - Press Release
• Cannasat Therapeutics and IntelGenx Corp. Reach Key Milestone 9/17 - Press Release
• Scientific Results Presented at ICAAC demonstrate the Well-Differentiated Profile and Broad Spectrum of BioAlliance Pharma’s Antifungal 9/17 - Press Release
• Pervasis Therapeutics announces New Animal Study Results Supporting Vascugel™ in Promoting Healing after Blood Vessel Injury 9/17 - Press Release
• Final Report of Ushercell as Treatment for Bacterial Vaginosis Released 9/17 - Prime Newswire
• orBec(R) Clinical Review Published in "Expert Review of Clinical Immunology" 9/17 - Marketwire
• MicroIslet and Progenitor Cell Therapy Enter Into Agreement for the Manufacturing of MicroIslet-P, an Encapsulated Islet Cell Product for the Treatment of Type 1 Diabetes 9/17 - Prime Newswire
• Oculus Innovative Sciences Provides Update of Phase II Study for Microcyn® Technology in Mildly Infected Diabetic Foot Ulcers 9/17 - Press Release
• Kamada to Start phase II Clinical Trials of the Aerosolized Form of AAT for the Treatment of Cystic Fibrosis; Following Successful Discussions with EMEA 9/16 - Press Release

Technology News

• GenVec Technology Demonstrates Selective Anti-Cancer Activity 9/20 - Press Release

• Alnylam and Collaborators Publish New Research on the In Vivo Mechanisms for Systemic Delivery of RNAi Therapeutics 9/17 - Press Release

Latest DDS Patents

• Urigen Pharmaceuticals Announces Issued Patent 9/21 - Businesswire
• Actavis Confirms its Patent Challenge of King’s Avinza® 9/17 - Press Release
• See latest patents section

Financial/Company News

• MicroIslet Receives $1 Million Working Capital Loan 9/21 - Prime Newswire
• Trial Date Set for Patent Infringement Suit Against Sepracor's Brovana(TM) 9/21 - PR Newswire
• Acusphere to Increase Focus on Partnering Opportunities 9/19 - Press Release
• Nektar Therapeutics Creates New PEGylation and Pulmonary Research Units to Drive Innovative Technology-Based Product Pipeline 9/18 - PR Newswire
• Depomed Announces Reduction in Force 9/17 - Press Release

People News

• None for week